Porphyrins and Phthalocyanines for Theranostics

Porphyrins and Phthalocyanines for Theranostics

The field of theranostics is growing rapidly as therapeutic regimes are increasingly being integrated and guided by diagnostic practices such as medical imaging. There is some room for discussion about the general definition of a theranostic agent, if there exists such a definition. Is it a diagnostic imaging agent that is used in the context to guide surgical procedures? Or rather, is it a the...

Unique Diagnostic and Therapeutic Roles of Porphyrins and Phthalocyanines in Photodynamic Therapy, Imaging and Theranostics

Porphyrinic molecules have a unique theranostic role in disease therapy; they have been used to image, detect and treat different forms of diseased tissue including age-related macular degeneration and a number of different cancer types. Current focus is on the clinical imaging of tumour tissue; targeted delivery of photosensitisers and the potential of photosensitisers in multimodal biomedical...

Photochemical Transformations Involving Porphyrins and Phthalocyanines

2 1. Introduction Photochemistry of the porphyrins and their relatives has been largely inspired by photosynthetic processes in nature. As a result of this, most current studies generally utilize the chemistry of magnesium and zinc porphyrin analogues. Especially, magnesium tetrapyrrole chelates, i.e. magnesium porphyrins and phthalocyanines have found wide interest. This is primarily related t...

Singlet oxygen generation of porphyrins, chlorins, and phthalocyanines.

The production of singlet oxygen was measured indirectly for three classes of photosensitizers: porphyrins (Photofrin II, TPPS4), chlorins (MACE, DACE), and a phthalocyanine (CASPc). Buffered solutions of sensitizers and singlet oxygen acceptors were irradiated with a CW dye laser and the oxygen depletion was monitored electrochemically with a Clark-type microelectrode. A comparison of oxygen-d...

Novel therapeutic uses for porphyrins and phthalocyanines in the transmissible spongiform encephalopathies.